Endocrine Abstracts

Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition which leads to glucocorticoid deficiency. During childhood, aims of treatment are to prevent adrenal crisis and to achieve optimal adult height and normal puberty. In adults, aims of treatment are to prevent adrenal crisis, ensure normal fertility and avoid long-term consequences of glucocorticoid use. Current regimens with glucocorticoids cannot optimally replicate the normal physiological cortisol level...

The purpose of the work: to compare the changes in the global longitudinal strain of the left ventricle in obese patients with and without COPD.Material and methods of research: group I consisted of obese patients without COPD (n=50; 21 - males, mean age - 48.8±9.1 years). Group II – 40 patients with obesity and COPD, comparable in age, gender. Group III – 37 patients with COPD without obesity, comparable in age, gender and risk g...

Background: The hypothalamic neuropeptides kisspeptin and neurokinin B (NKB) are both obligate for normal gonadotrophin secretion. Studies in patients with loss-of-function mutations in NKB signalling suggest that kisspeptin is functionally upstream of NKB, but this hierarchy is unexplored in healthy men and women. We hypothesised that kisspeptin augmentation of estrogen-induced mid-cycle LH secretion will not be abrogated by pharmacological blockade of NKB.<p class="abste...

Introduction: Lymphocytic hypophysitis (LH) is a rare condition that has been increasingly recognised. We studied the natural history and current management of patients with lymphocytic hypophysitis.Methods: We performed a multi-centre retrospective review of all patients that either had histologically proven disease or a strong clinical suspicion for its presence, diagnosed from 2000 onwards. Cases of secondary hypophysitis or granulomatous or xanthomat...

Free radicals and reactive oxygen species (ROS) participate in physiological and pathological processes in the thyroid gland. Oxidative stress caused by ROS is involved in many types of DNA damage that are associated with the initiation or the progression of numerous human cancers including thyroid tumors. One of the most mutagenic products of oxygen radical forming agents is 7,8-dihydro-8-oxoguanine (8-oxoG). The aim of the current study was to investigate expression of OGG1 ...

Endocrinopathies are one of the most common side effects induced by immunotherapy. The side effects result from the activation of immune system, which affects not only cancerous but also healthy body cells. In most cases, only one endocrinopathy occurs, but in our presented case we describe multiple endocrinopathies that occurred to a one person. 53-years-old male patient was referred to the Emergency department due to severe hyperglycemia (37.13 mmol/l) and the following symp...

McCune-Albright syndrome (MAS) is a rare mosaic disorder caused by a postzygotic activating mutation in the GNAS gene encoding the G protein alpha subunit. Although clinical manifestations may be heterogeneous, MAS is often characterized by the triad of fibrous dysplasia, café-au-lait skin pigmentations and hyperfunctioning endocrinopathy. We report here a 58-year old woman who presented for evaluation of hyperthyroidism, associated with nodular thyroid disease and elevat...

Introduction: Adrenocortical carcinomas (ACC) are rare and frequently aggressive tumors that may be functional (hormone-secreting) – causing Cushing’s syndrome and/or virilization, or nonfunctional – presenting as an abdominal mass or as an incidental finding. We describe a rare case of stage IV adrenocortical carcinoma which first manifested as treatment resistant Cushing’s syndrome.Case report: In september of 2021, a 24-year-old fe...

We present two case reports of patients who were diagnosed with hyperparathyroidism based on a parathyroid gland adenoma (PTA). The pathological parathyroid tissue was precisely localised by ultrasonography and scintigraphy before the surgery. In both cases all four parathyroid glands were revised by the surgeon resulting in an operation extension. Another parathyroid gland was removed and histologically confirmed as PTA. This surgeon’s approach was beneficial for the pat...

A 51-year-old obese lady was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. She was referred to the endocrine team because of newly-diagnosed type 2 diabetes mellitus. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis (BSAN) led to a clinical diagnosis of Cushing’s syndrome (CS); this was biochemically confirmed as follows: non-s...